In the context of this collaboration, the project is investigating three main axes of research: (1) designing and using sounds as a way to explore states of consciousness in coma (ex. sounds of laughter to see if a patient smiles back). The challenge of this axis is to create sounds (or sound apparatus) that are both emotionally meaningful and possibly personalized for the patient, and at the same type fit the requirements of clinical investigation (e.g. short, repeatable for EEG examinations). Prototypes sounds will be tested in the context of routine electrophysiological examinations in the ICU, in collaboration with doctors from Hospital Saint-Anne (2) creating and using sonic/musical textures to improve the ICU soundscape and provide a more therapeutic environment (ex. spatialized musical textures to decrease anxiety in patients and family). The challenge of this axis is to create sounds (or sound apparatus) that have both a suitable form to be used in a daily clinical environment (e.g. not overwhelming or distracting for the practice of caregivers) and a content that has beneficial properties for the patient recovery (e.g. reducing anxiety, comforting, providing a sense of privacy or safety). Prototype sounds will be tested in the context of IRCAM studios, and may be deployed with custom sound diffusion (multi-speaker, etc.) systems in the ICU. (3) designing more informative and less anxious alarms for ICU scopes and equipments (ex. sound alarms adaptive to actual medical emergency). The challenge of this axis is to create alarm sounds (or sound apparatus) that are both distinctive and informative (e.g. one should not miss a critical alarm) and that improve the environment (e.g. by facilitating the attribution of a given alarm to a given piece of equipment, avoid unnecessary call of attention, decrease anxiety). Sound prototypes will be tested in the lab, and their integration in actual medical equipement will be attempted in collaboration with technical staff at the Saint-Anne Hospital.